A DROSOPHILA MODEL OF DOMINANT INCLUSION BODY MYOPATHY TYPE 3 SHOWS DIMINISHED MYOSIN KINETICS THAT REDUCE MUSCLE POWER AND YIELD MYOFIBRILLAR DEFECTS

Individuals with inclusion body myopathy type 3 (IBM3) display congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood.The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa.We have previously expressed the corresponding myosin mutation (

Background and objective Gefitinib is an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) that has been widely used for the treatment of non-small cell lung cancer (NSCLC).It is most effective in women, as well as in patients who have never smoked, have pulmonary adenocarcinomas, or are of Asian origin.Several treatment options

This paper analyses how religious minorities in West Pasaman and Dharmasraya have been disturbed by the implementation of regional autonomy policies.By examining the church establishment and Islamic clothing enactment in the region as case studies, the paper shows that the conflicts between Muslims and Christians were caused by the discriminatory r

The timely and accurate recognition of damage to buildings after destructive disasters is one of the most important post-event responses.Due to the complex and dangerous situations in affected areas, field surveys of post-disaster conditions are not always feasible.The use of satellite imagery for disaster assessment can overcome this problem.Howev